Bilateral paraneoplastic optic neuropathy and unilateral retinal compromise in association with prostate cancer: a differential diagnostic challenge in a patient with unexplained visual loss

We report a 77-year-old Caucasian man with a 1-year complaint of unexplained visual loss and a 4-year history of prostate cancer. A complete ophthalmologic exam, Goldmann visual fields (GVFs), intravenous fluorescein angiography (IVFA), macular and disc optical coherence tomography (OCT), pattern-reversal visual evoked potentials (PVEPs), and flash electroretinograms (ERGs) were performed. On examination, visual acuity was reduced bilaterally. Fundus exam showed juxtapapillary changes (OS > OD) and, in OS, disc pallor, peripheral RPE dropout and whitish retinal discoloration along the arcades. OCTs were normal OU. Cancer-associated retinopathy (CAR) was suspected. A flash ERG was normal OD and markedly reduced and electronegative OS. An IVFA showed bilateral juxtapapilla...

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MicroRNA-199a* regulates the expression of cyclooxygenase-2 in human chondrocytes

ConclusionsmiR-199a* is a direct regulator of COX-2 expression in OA chondrocytes. IL-1β-induced activation of p38-MAPK correlates inversely with miR199a* expression levels. miR-199a* may be an important regulator of human cartilage homeostasis and a new target for OA therapy. (Source: Annals of the Rheumatic Diseases)

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Only on InStyle: Heidi Klum offers up her nine rules for perfect locks (because really, who doesn't want her hair?) and reveals her favorite styles of all time.
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Most women dream to just stay home and start a business and be there own boss! Well, that dream can become a reality right now. If you want to start the best business for women in 2012, you cannot do better than start a Bear Stuffing Business today! This may seem rather new but the [...]
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